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ea0063gp9 | Adrenal and Neuroendocrine - Tumour | ECE2019

IGF-1 splice variants’ expression in adrenal gland neoplasms- Possible role in adrenal tumorigenesis

Kyriakopoulos Georgios , Nasiri-Ansari Narjes , Angelousi Anna , Philippou Anastasios , Karapanagioti Angeliki , Zografos Georgios , Aggeli Chrysanthi , Choreftaki Theodosia , Tiniakos Dina , Rontogianni Dimitra , Dimitriadis Georgios , Kaltsas Gregory , Papavassiliou Athanasios G. , Kassi Eva

Introduction: IGF-1 overexpression has been associated with tumorigenesis. IGF-1Ea, IGF-1Eb and IGF-1Ec isoforms were shown to be regulated differently in cancer. IGF-1Ec and IGF-1Eb overexpression has been positively associated with cell survival and proliferation in various tumors. Elevated IGF1Eb/IGF-1Ea ratio has been suggested as a biomarker of cervical cancer prognosis. Herein, we aimed to examine the expression of IGF-1 isoforms in human adrenocortical carcinomas (ACCs)...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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